3H52
Crystal structure of the antagonist form of human glucocorticoid receptor
Summary for 3H52
Entry DOI | 10.2210/pdb3h52/pdb |
Descriptor | Glucocorticoid receptor, Nuclear receptor corepressor 1, 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE, ... (5 entities in total) |
Functional Keywords | protein-ligand complex, nuclear receptor, peptide complex, hormone receptor 3, hormone receptor |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm. Isoform Beta: Nucleus: P04150 Nucleus (By similarity): O75376 |
Total number of polymer chains | 6 |
Total formula weight | 123175.56 |
Authors | Schoch, G.A.,Benz, J.,D'Arcy, B.,Stihle, M.,Burger, D.,Thoma, R.,Ruf, A. (deposition date: 2009-04-21, release date: 2009-12-01, Last modification date: 2023-11-01) |
Primary citation | Schoch, G.A.,D'Arcy, B.,Stihle, M.,Burger, D.,Bar, D.,Benz, J.,Thoma, R.,Ruf, A. Molecular switch in the glucocorticoid receptor: active and passive antagonist conformations J.Mol.Biol., 395:568-577, 2010 Cited by PubMed: 19913032DOI: 10.1016/j.jmb.2009.11.011 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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