3H52
Crystal structure of the antagonist form of human glucocorticoid receptor
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 486 A 3 |
| Chain | Residue |
| A | ASN564 |
| A | MET752 |
| A | GLY567 |
| A | GLN570 |
| A | VAL571 |
| A | MET601 |
| A | ARG611 |
| A | GLN642 |
| A | LEU732 |
| A | TYR735 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 486 B 1 |
| Chain | Residue |
| B | MET560 |
| B | LEU563 |
| B | ASN564 |
| B | GLY567 |
| B | GLY568 |
| B | GLN570 |
| B | VAL571 |
| B | ARG611 |
| B | MET639 |
| B | GLN642 |
| B | MET646 |
| B | TYR735 |
| B | LEU753 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 778 |
| Chain | Residue |
| B | HIS645 |
| B | GLU727 |
| B | ASN731 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 486 C 4 |
| Chain | Residue |
| C | LEU563 |
| C | GLY567 |
| C | GLN570 |
| C | MET604 |
| C | ARG611 |
| C | PHE623 |
| C | MET639 |
| C | PHE740 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 486 D 2 |
| Chain | Residue |
| D | LEU563 |
| D | ASN564 |
| D | GLY567 |
| D | GLN570 |
| D | VAL571 |
| D | MET601 |
| D | MET604 |
| D | ARG611 |
| D | PHE623 |
| D | MET639 |
| D | TYR735 |
| D | LEU753 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 660 |
| Details | Region: {"description":"Interaction with CRY1","evidences":[{"source":"PubMed","id":"22170608","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"12144530","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Motif: {"description":"CORNR box 3"} |
| Chain | Residue | Details |
