3H52
Crystal structure of the antagonist form of human glucocorticoid receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Glucocorticoid receptor | polymer | 254 | 29315.1 | 4 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (Human) | GR, Nuclear receptor subfamily 3 group C member 1 |
| 2 | E, F (N, M) | Nuclear receptor corepressor 1 | polymer | 19 | 2052.4 | 2 | UniProt (O75376) | N-CoR1, N-CoR | |
| 3 | G, H, J, K (A, B, C, D) | 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE | non-polymer | 429.6 | 4 | Chemie (486) | |||
| 4 | I (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | L, M, N, O, P... (A, B, C, D, N...) | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 528 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Gly 524 | - | expression tag |
| Ser 525 | - | expression tag |
| His 526 | - | expression tag |
| Met 527 | - | expression tag |
| Ser 602 | Phe 602 | engineered mutation |
| Asp 638 | Cys 638 | engineered mutation |
| Ala 684 | Glu 684 | engineered mutation |
| Ala 688 | Glu 688 | engineered mutation |
| Ser 712 | Trp 712 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 121365.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1810.5 | |
| All* | Total formula weight | 123175.6 |
