3H4G

Structure of aldehyde reductase holoenzyme in complex with potent aldose reductase inhibitor Fidarestat: Implications for inhibitor binding and selectivity

Replaces:  2AO0

Summary for 3H4G

• Entry DOI: 10.2210/pdb3h4g/pdb
• Related: 1PWM 3CV7
• Descriptor: Alcohol dehydrogenase [NADP+], SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• Functional Keywords: tim barrel, aldo-keto reductase, ternary complex, nadp, oxidoreductase
• Biological source: Sus scrofa (pigs)
• Total number of polymer chains: 1
• Total formula weight: 37745.65

Authors

Carbone, V.,El-Kabbani, O. (deposition date: 2009-04-20, release date: 2009-05-05, Last modification date: 2023-11-01)

• Primary citation: El-Kabbani, O.,Carbone, V.,Darmanin, C.,Oka, M.,Mitschler, A.,Podjarny, A.,Schulze-Briese, C.,Chung, R.P.; Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity; J.Med.Chem., 48:5536-5542, 2005; PubMed: 16107153; DOI: 10.1021/jm050412o

Experimental method

X-RAY DIFFRACTION (1.85 Å)