3H4G
Structure of aldehyde reductase holoenzyme in complex with potent aldose reductase inhibitor Fidarestat: Implications for inhibitor binding and selectivity
Replaces: 2AO0Summary for 3H4G
Entry DOI | 10.2210/pdb3h4g/pdb |
Related | 1PWM 3CV7 |
Descriptor | Alcohol dehydrogenase [NADP+], SULFATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | tim barrel, aldo-keto reductase, ternary complex, nadp, oxidoreductase |
Biological source | Sus scrofa (pigs) |
Total number of polymer chains | 1 |
Total formula weight | 37745.65 |
Authors | Carbone, V.,El-Kabbani, O. (deposition date: 2009-04-20, release date: 2009-05-05, Last modification date: 2023-11-01) |
Primary citation | El-Kabbani, O.,Carbone, V.,Darmanin, C.,Oka, M.,Mitschler, A.,Podjarny, A.,Schulze-Briese, C.,Chung, R.P. Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity J.Med.Chem., 48:5536-5542, 2005 Cited by PubMed: 16107153DOI: 10.1021/jm050412o PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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