3H06

Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282

3H06 の概要

• エントリーDOI: 10.2210/pdb3h06/pdb
• 関連するPDBエントリー: 3H03
• 分子名称: Glutamate receptor 2, 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid (3 entities in total)
• 機能のキーワード: glutamate receptor, glur2, ampa receptor, neurotransmitter receptor, s1s2, willardiine, membrane protein
• 由来する生物種: Rattus norvegicus; 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P19491
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 233348.93

構造登録者

Ahmed, A.H.,Oswald, R.E. (登録日: 2009-04-08, 公開日: 2009-05-05, 最終更新日: 2017-08-23)

• 主引用文献: Ahmed, A.H.,Thompson, M.D.,Fenwick, M.K.,Romero, B.,Loh, A.P.,Jane, D.E.,Sondermann, H.,Oswald, R.E.; Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain.; Biochemistry, 48:3894-3903, 2009; PubMed: 19284741; DOI: 10.1021/bi900107m

実験手法

X-RAY DIFFRACTION (2.8 Å)