3GQO

Crystal structure of macro domain of Venezuelan Equine Encephalitis virus in complex with ADP-ribose

3GQO の概要

• エントリーDOI: 10.2210/pdb3gqo/pdb
• 関連するPDBエントリー: 3GPG 3GPO 3GPQ 3GQE
• 分子名称: Non-structural protein 3, ADENOSINE-5-DIPHOSPHORIBOSE (3 entities in total)
• 機能のキーワード: macro domain, x domain, venezuelan equine encephalitis virus, alphavirus, virus, adp-ribose, vizier, viral enzymes involved in replication, viral protein
• 由来する生物種: Venezuelan equine encephalitis virus
• 細胞内の位置: Non-structural polyprotein: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . P123: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . P123': Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . mRNA-capping enzyme nsP1: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Protease nsP2: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 3: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 3': Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . RNA-directed RNA polymerase nsP4: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side : P36328
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 75696.75

構造登録者

Malet, H.,Jamal, S.,Coutard, B.,Ferron, F.,Canard, B. (登録日: 2009-03-24, 公開日: 2009-07-21, 最終更新日: 2023-09-06)

• 主引用文献: Malet, H.,Coutard, B.,Jamal, S.,Dutartre, H.,Papageorgiou, N.,Neuvonen, M.,Ahola, T.,Forrester, N.,Gould, E.A.,Lafitte, D.,Ferron, F.,Lescar, J.,Gorbalenya, A.E.,de Lamballerie, X.,Canard, B.; The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket; J.Virol., 83:6534-6545, 2009; PubMed: 19386706; DOI: 10.1128/JVI.00189-09

実験手法

X-RAY DIFFRACTION (2.6 Å)