3GQO

Crystal structure of macro domain of Venezuelan Equine Encephalitis virus in complex with ADP-ribose

3GQO の概要

関連するPDBエントリー3GPG 3GPO 3GPQ 3GQE
分子名称Non-structural protein 3, ADENOSINE-5-DIPHOSPHORIBOSE (3 entities in total)
機能のキーワードmacro domain, x domain, venezuelan equine encephalitis virus, alphavirus, virus, adp-ribose, vizier, viral enzymes involved in replication, viral protein
由来する生物種Venezuelan equine encephalitis virus
細胞内の位置Non-structural polyprotein: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . P123: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . P123': Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . mRNA-capping enzyme nsP1: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Protease nsP2: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 3: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 3': Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . RNA-directed RNA polymerase nsP4: Host endosome membrane ; Peripheral membrane protein ; Cytoplasmic side  P36328
ポリマー鎖数4
分子量合計75696.75
構造登録者
Malet, H.,Jamal, S.,Coutard, B.,Ferron, F.,Canard, B. (登録日: 2009-03-24, 公開日: 2009-07-21, 最終更新日: 2017-09-20)
主引用文献
Malet, H.,Coutard, B.,Jamal, S.,Dutartre, H.,Papageorgiou, N.,Neuvonen, M.,Ahola, T.,Forrester, N.,Gould, E.A.,Lafitte, D.,Ferron, F.,Lescar, J.,Gorbalenya, A.E.,de Lamballerie, X.,Canard, B.
The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket
J.Virol., 83:6534-6545, 2009
PubMed: 19386706 (主引用文献が同じPDBエントリー)
DOI: 10.1128/JVI.00189-09
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.6 Å)
?

構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.26280.2%6.8%0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード