3GQF

Structural and Biophysical Properties of the Pathogenic SOD1 Variant H46R/H48Q

Summary for 3GQF

• Entry DOI: 10.2210/pdb3gqf/pdb
• Related: 2NNX
• Descriptor: Superoxide dismutase [Cu-Zn], ZINC ION, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: human cu-zn superoxide dismutase, superoxide acceptor, familial amyotrophic lateral sclerosis mutant, acetylation, amyotrophic lateral sclerosis, antioxidant, copper, cytoplasm, disease mutation, disulfide bond, metal-binding, oxidoreductase, phosphoprotein, ubl conjugation, zinc
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P00441
• Total number of polymer chains: 6
• Total formula weight: 95612.38

Authors

Winkler, D.D.,Schuermann, J.P.,Hart, P.J. (deposition date: 2009-03-24, release date: 2009-04-07, Last modification date: 2023-09-06)

• Primary citation: Winkler, D.D.,Schuermann, J.P.,Cao, X.,Holloway, S.P.,Borchelt, D.R.,Carroll, M.C.,Proescher, J.B.,Culotta, V.C.,Hart, P.J.; Structural and biophysical properties of the pathogenic SOD1 variant H46R/H48Q.; Biochemistry, 48:3436-3447, 2009; PubMed: 19227972; DOI: 10.1021/bi8021735

Experimental method

X-RAY DIFFRACTION (2.2 Å)