2NNX
Crystal Structure of the H46R, H48Q double mutant of human [Cu-Zn] Superoxide Dismutase
Summary for 2NNX
Entry DOI | 10.2210/pdb2nnx/pdb |
Descriptor | SUPEROXIDE DISMUTASE [CU-ZN], ZINC ION, SULFATE ION, ... (4 entities in total) |
Functional Keywords | oxidoreductase; human; cu-zn superoxide dismutase; superoxide acceptor; familial amyotrophic lateral sclerosis mutant, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 64069.85 |
Authors | Schuermann, J.P.,Hart, P.J. (deposition date: 2006-10-24, release date: 2006-11-07, Last modification date: 2023-08-30) |
Primary citation | Wang, J.,Caruano-Yzermans, A.,Rodriguez, A.,Scheurmann, J.P.,Slunt, H.H.,Cao, X.,Gitlin, J.,Hart, P.J.,Borchelt, D.R. Disease-associated mutations at copper ligand histidine residues of superoxide dismutase 1 diminish the binding of copper and compromise dimer stability J.Biol.Chem., 282:345-352, 2007 Cited by PubMed: 17092942DOI: 10.1074/jbc.M604503200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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