3GPC

Crystal structure of human Acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in a complex with CoA

Replaces:  3EYN

Summary for 3GPC

• Entry DOI: 10.2210/pdb3gpc/pdb
• Related: 3B7W 3C5E 3DAY 3EQ6
• Descriptor: Acyl-coenzyme A synthetase ACSM2A, MAGNESIUM ION, COENZYME A, ... (4 entities in total)
• Functional Keywords: middle-chain acyl-coa synthetase, xenobiotic/medium-chain fatty acid-coa ligase, atp-binding, fatty acid metabolism, lipid metabolism, magnesium, metal-binding, mitochondrion, nucleotide-binding polymorphism, transit peptide, ligase, nucleotide-binding
• Biological source: Homo sapiens (Human)
• Cellular location: Mitochondrion matrix : Q08AH3
• Total number of polymer chains: 2
• Total formula weight: 128252.80

Authors

Pilka, E.S.,Kochan, G.T.,Yue, W.W.,Bhatia, C.,Von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Oppermann, U.,Structural Genomics Consortium (SGC) (deposition date: 2009-03-23, release date: 2009-04-07, Last modification date: 2023-11-01)

• Primary citation: Kochan, G.,Pilka, E.S.,von Delft, F.,Oppermann, U.,Yue, W.W.; Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A; J.Mol.Biol., 388:997-1008, 2009; PubMed: 19345228; DOI: 10.1016/j.jmb.2009.03.064

Experimental method

X-RAY DIFFRACTION (1.9 Å)