3GPC
Crystal structure of human Acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in a complex with CoA
Replaces: 3EYNFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004321 | molecular_function | fatty-acyl-CoA synthase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0006637 | biological_process | acyl-CoA metabolic process |
| A | 0015645 | molecular_function | fatty acid ligase activity |
| A | 0016405 | molecular_function | CoA-ligase activity |
| A | 0016874 | molecular_function | ligase activity |
| A | 0016878 | molecular_function | acid-thiol ligase activity |
| A | 0018858 | molecular_function | benzoate-CoA ligase activity |
| A | 0031956 | molecular_function | medium-chain fatty acid-CoA ligase activity |
| A | 0036112 | biological_process | medium-chain fatty-acyl-CoA metabolic process |
| A | 0042593 | biological_process | glucose homeostasis |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070328 | biological_process | triglyceride homeostasis |
| A | 0102391 | molecular_function | decanoate-CoA ligase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004321 | molecular_function | fatty-acyl-CoA synthase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006631 | biological_process | fatty acid metabolic process |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0006637 | biological_process | acyl-CoA metabolic process |
| B | 0015645 | molecular_function | fatty acid ligase activity |
| B | 0016405 | molecular_function | CoA-ligase activity |
| B | 0016874 | molecular_function | ligase activity |
| B | 0016878 | molecular_function | acid-thiol ligase activity |
| B | 0018858 | molecular_function | benzoate-CoA ligase activity |
| B | 0031956 | molecular_function | medium-chain fatty acid-CoA ligase activity |
| B | 0036112 | biological_process | medium-chain fatty-acyl-CoA metabolic process |
| B | 0042593 | biological_process | glucose homeostasis |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070328 | biological_process | triglyceride homeostasis |
| B | 0102391 | molecular_function | decanoate-CoA ligase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 901 |
| Chain | Residue |
| A | MET483 |
| A | HIS485 |
| A | VAL488 |
| A | HOH957 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE COA A 578 |
| Chain | Residue |
| A | TYR361 |
| A | GLY362 |
| A | GLN363 |
| A | THR364 |
| A | LEU444 |
| A | ASP446 |
| A | PHE458 |
| A | ARG461 |
| A | THR553 |
| A | THR555 |
| A | LYS557 |
| A | GLN559 |
| A | HOH590 |
| A | HOH687 |
| A | HOH697 |
| A | HOH780 |
| A | HOH781 |
| A | HOH785 |
| A | HOH918 |
| A | HOH1143 |
| A | GLY338 |
| A | GLU339 |
| A | SER340 |
| A | GLU359 |
| A | SER360 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 901 |
| Chain | Residue |
| B | MET483 |
| B | HIS485 |
| B | VAL488 |
| B | HOH611 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE COA B 902 |
| Chain | Residue |
| B | TRP265 |
| B | GLY338 |
| B | GLU339 |
| B | SER340 |
| B | GLU359 |
| B | SER360 |
| B | TYR361 |
| B | GLY362 |
| B | GLN363 |
| B | THR364 |
| B | ASP446 |
| B | PHE458 |
| B | ARG461 |
| B | THR555 |
| B | HOH718 |
| B | HOH787 |
| B | HOH788 |
| B | HOH794 |
| B | HOH1192 |
Functional Information from PROSITE/UniProt
| site_id | PS00455 |
| Number of Residues | 12 |
| Details | AMP_BINDING Putative AMP-binding domain signature. IYFTSGTSGlPK |
| Chain | Residue | Details |
| A | ILE218-LYS229 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19345228","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"19345228","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"PDB data bank","title":"Crystal structure of L64P mutant of human acyl-CoA synthetase medium-chain family member 2A.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q68CK6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
