3GLK

The biotin carboxylase (BC) domain of human Acetyl-CoA Carboxylase 2 (ACC2)

Summary for 3GLK

Entry DOI	10.2210/pdb3glk/pdb
Related	3GID
Descriptor	Acetyl-CoA carboxylase 2 (2 entities in total)
Functional Keywords	atp binding, carboxylase, atp-binding, biotin, fatty acid biosynthesis, ligase, lipid synthesis, manganese, membrane, metal-binding, multifunctional enzyme, nucleotide-binding, phosphoprotein, acc2-bc
Biological source	Homo sapiens (human)
Cellular location	Mitochondrion : O00763
Total number of polymer chains	1
Total formula weight	60092.95
Authors	Price, A.,Kulathila, R. (deposition date: 2009-03-12, release date: 2009-03-24, Last modification date: 2024-02-21)
Primary citation	Raymer, B.,Kavana, M.,Price, A.,Wang, B.,Corcoran, L.,Kulathila, R.,Groarke, J.,Mann, T. Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase. Bioorg.Med.Chem.Lett., 19:2804-2807, 2009 Cited by PubMed Abstract: BODIPY-labeled Soraphen A derivative 4 was synthesized and characterized as an acetyl-CoA carboxylase (ACC) binder. Biophysical measurements indicate that the molecule binds in the biotin carboxylase domain where Soraphen A has been shown to bind. The fluorescent label of the BODIPY can be used to biophysically identify a compound that binds to the Soraphen A site of the biotin carboxylase domain versus the carboxytransferase domain of ACC. PubMed: 19359168 DOI: 10.1016/j.bmcl.2009.03.107 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation