3GH0

Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability

Summary for 3GH0

• Entry DOI: 10.2210/pdb3gh0/pdb
• Related: 1HW3 3EAW 3EBU 3ED7 3EDW 3EF9 3EJL 3GG5 3GH2
• Descriptor: Thymidylate synthase, SULFATE ION (3 entities in total)
• Functional Keywords: transferase, methyltransferase, nucleotide biosynthesis
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P04818
• Total number of polymer chains: 1
• Total formula weight: 36065.15

Authors

Huang, X.,Gibson, L.M.,Bell, B.J.,Lovelace, L.L.,Lebioda, L. (deposition date: 2009-03-02, release date: 2010-03-02, Last modification date: 2024-02-21)

• Primary citation: Huang, X.,Gibson, L.M.,Bell, B.J.,Lovelace, L.L.,Pena, M.M.,Berger, F.G.,Berger, S.H.,Lebioda, L.; Replacement of Val3 in human thymidylate synthase affects its kinetic properties and intracellular stability .; Biochemistry, 49:2475-2482, 2010; PubMed: 20151707; DOI: 10.1021/bi901457e

Experimental method

X-RAY DIFFRACTION (1.56 Å)