3GEP

Human hypoxanthine guanine phosphoribosyltranserfase in complex with (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)guanine

3GEP の概要

• エントリーDOI: 10.2210/pdb3gep/pdb
• 関連するPDBエントリー: 1BZY 1D6N 1HMP 1Z7G
• 分子名称: Hypoxanthine-guanine phosphoribosyltransferase, {[(1S)-2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-1-(hydroxymethyl)ethoxy]methyl}phosphonic acid (3 entities in total)
• 機能のキーワード: phosphoribosyltransferase, acyclic nucleoside phosphonate, purine salvage pathway, malarial chemotherapeutic, acetylation, cytoplasm, disease mutation, glycosyltransferase, gout, magnesium, metal-binding, purine salvage, transferase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P00492
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49600.86

構造登録者

Guddat, L.W.,Keough, D.T.,Jersey, J. (登録日: 2009-02-25, 公開日: 2009-08-18, 最終更新日: 2023-11-01)

• 主引用文献: Keough, D.T.,Hockova, D.,Holy, A.,Naesens, L.M.,Skinner-Adams, T.S.,Jersey, J.,Guddat, L.W.; Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics.; J.Med.Chem., 52:4391-4399, 2009; PubMed: 19527031; DOI: 10.1021/jm900267n

実験手法

X-RAY DIFFRACTION (2.6 Å)