3GD2
isoxazole ligand bound to farnesoid X receptor (FXR)
Summary for 3GD2
Entry DOI | 10.2210/pdb3gd2/pdb |
Descriptor | Bile acid receptor, activator peptide, 3-[(E)-2-(2-chloro-4-{[3-{[(R)-(2,6-dichlorophenyl)(hydroxy)-lambda~4~-sulfanyl]methyl}-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)ethenyl]benzoic acid, ... (4 entities in total) |
Functional Keywords | fxr, nuclear recptor, activator, alternative splicing, dna-binding, metal-binding, nucleus, receptor, repressor, transcription, transcription regulation, zinc, zinc-finger, transcription-transcription activator complex, transcription/transcription activator |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus . Isoform 1: Nucleus . Isoform 2: Nucleus . Isoform 3: Nucleus . Isoform 4: Nucleus : Q96RI1 |
Total number of polymer chains | 2 |
Total formula weight | 28678.06 |
Authors | Madauss, K.P.,Williams, S.P.,Deaton, D.N.,Wisely, G.B.,Mcfadyen, R.B. (deposition date: 2009-02-23, release date: 2009-07-07, Last modification date: 2024-02-21) |
Primary citation | Bass, J.Y.,Caldwell, R.D.,Caravella, J.A.,Chen, L.,Creech, K.L.,Deaton, D.N.,Madauss, K.P.,Marr, H.B.,McFadyen, R.B.,Miller, A.B.,Parks, D.J.,Todd, D.,Williams, S.P.,Wisely, G.B. Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064. Bioorg.Med.Chem.Lett., 19:2969-2973, 2009 Cited by PubMed: 19410460DOI: 10.1016/j.bmcl.2009.04.047 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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