3GD2
isoxazole ligand bound to farnesoid X receptor (FXR)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Bile acid receptor | polymer | 229 | 26756.6 | 1 | UniProt (Q96RI1) Pfam (PF00104) In PDB | Homo sapiens (Human) | Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14 |
| 2 | B | activator peptide | polymer | 11 | 1314.5 | 1 | |||
| 3 | A | 3-[(E)-2-(2-chloro-4-{[3-{[(R)-(2,6-dichlorophenyl)(hydroxy)-lambda~4~-sulfanyl]methyl}-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)ethenyl]benzoic acid | non-polymer | 606.9 | 1 | Chemie (708) | |||
| 4 | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence modifications
A: 246 - 472 (UniProt: Q96RI1)
| PDB | External Database | Details |
|---|---|---|
| Gly 244 | - | expression tag |
| Ser 245 | - | expression tag |
| Glu 432 | Cys 446 | engineered mutation |
| Glu 466 | Cys 480 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28071.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 606.9 | |
| All* | Total formula weight | 28678.1 |
