3GC9

The structure of p38beta C119S, C162S in complex with a dihydroquinazolinone inhibitor

Summary for 3GC9

• Entry DOI: 10.2210/pdb3gc9/pdb
• Related: 3GC7 3GC8
• Descriptor: Mitogen-activated protein kinase 11, SODIUM ION, 5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-[1-(1-methylethyl)piperidin-4-yl]-3,4-dihydroquinazolin-2(1H)-one, ... (5 entities in total)
• Functional Keywords: serine/threonine kinase, drug design, selectivity, atp-binding, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 85266.73

Authors

Scapin, G.,Patel, S.B. (deposition date: 2009-02-21, release date: 2009-07-21, Last modification date: 2023-09-06)

• Primary citation: Patel, S.B.,Cameron, P.M.,O'Keefe, S.J.,Frantz-Wattley, B.,Thompson, J.,O'Neill, E.A.,Tennis, T.,Liu, L.,Becker, J.W.,Scapin, G.; The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha.; Acta Crystallogr.,Sect.D, 65:777-785, 2009; PubMed: 19622861; DOI: 10.1107/S090744490901600X

Experimental method

X-RAY DIFFRACTION (2.05 Å)