3GC7
The structure of p38alpha in complex with a dihydroquinazolinone
Summary for 3GC7
Entry DOI | 10.2210/pdb3gc7/pdb |
Related | 3GC8 3GC9 |
Descriptor | Mitogen-activated protein kinase 14, 5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-[1-(1-methylethyl)piperidin-4-yl]-3,4-dihydroquinazolin-2(1H)-one (3 entities in total) |
Functional Keywords | serine/threonine kinase, inhibitor design, selectivity, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 42529.76 |
Authors | Scapin, G.,Patel, S.B. (deposition date: 2009-02-21, release date: 2009-07-21, Last modification date: 2024-02-21) |
Primary citation | Patel, S.B.,Cameron, P.M.,O'Keefe, S.J.,Frantz-Wattley, B.,Thompson, J.,O'Neill, E.A.,Tennis, T.,Liu, L.,Becker, J.W.,Scapin, G. The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha. Acta Crystallogr.,Sect.D, 65:777-785, 2009 Cited by PubMed: 19622861DOI: 10.1107/S090744490901600X PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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