3GC7

The structure of p38alpha in complex with a dihydroquinazolinone

Summary for 3GC7

Entry DOI	10.2210/pdb3gc7/pdb
Related	3GC8 3GC9
Descriptor	Mitogen-activated protein kinase 14, 5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-[1-(1-methylethyl)piperidin-4-yl]-3,4-dihydroquinazolin-2(1H)-one (3 entities in total)
Functional Keywords	serine/threonine kinase, inhibitor design, selectivity, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	42529.76
Authors	Scapin, G.,Patel, S.B. (deposition date: 2009-02-21, release date: 2009-07-21, Last modification date: 2024-02-21)
Primary citation	Patel, S.B.,Cameron, P.M.,O'Keefe, S.J.,Frantz-Wattley, B.,Thompson, J.,O'Neill, E.A.,Tennis, T.,Liu, L.,Becker, J.W.,Scapin, G. The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha. Acta Crystallogr.,Sect.D, 65:777-785, 2009 Cited by PubMed: 19622861 DOI: 10.1107/S090744490901600X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation