3GC9
The structure of p38beta C119S, C162S in complex with a dihydroquinazolinone inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000165 | biological_process | MAPK cascade |
A | 0001649 | biological_process | osteoblast differentiation |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004674 | molecular_function | protein serine/threonine kinase activity |
A | 0004707 | molecular_function | MAP kinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006468 | biological_process | protein phosphorylation |
A | 0010628 | biological_process | positive regulation of gene expression |
A | 0031098 | biological_process | stress-activated protein kinase signaling cascade |
A | 0032735 | biological_process | positive regulation of interleukin-12 production |
A | 0035556 | biological_process | intracellular signal transduction |
A | 0038066 | biological_process | p38MAPK cascade |
A | 0045648 | biological_process | positive regulation of erythrocyte differentiation |
A | 0051149 | biological_process | positive regulation of muscle cell differentiation |
A | 0051403 | biological_process | stress-activated MAPK cascade |
A | 0060038 | biological_process | cardiac muscle cell proliferation |
A | 0060043 | biological_process | regulation of cardiac muscle cell proliferation |
A | 0060044 | biological_process | negative regulation of cardiac muscle cell proliferation |
A | 0060348 | biological_process | bone development |
A | 0071347 | biological_process | cellular response to interleukin-1 |
A | 0071493 | biological_process | cellular response to UV-B |
A | 0090398 | biological_process | cellular senescence |
A | 0098586 | biological_process | cellular response to virus |
A | 0106310 | molecular_function | protein serine kinase activity |
B | 0000165 | biological_process | MAPK cascade |
B | 0001649 | biological_process | osteoblast differentiation |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004674 | molecular_function | protein serine/threonine kinase activity |
B | 0004707 | molecular_function | MAP kinase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006468 | biological_process | protein phosphorylation |
B | 0010628 | biological_process | positive regulation of gene expression |
B | 0031098 | biological_process | stress-activated protein kinase signaling cascade |
B | 0032735 | biological_process | positive regulation of interleukin-12 production |
B | 0035556 | biological_process | intracellular signal transduction |
B | 0038066 | biological_process | p38MAPK cascade |
B | 0045648 | biological_process | positive regulation of erythrocyte differentiation |
B | 0051149 | biological_process | positive regulation of muscle cell differentiation |
B | 0051403 | biological_process | stress-activated MAPK cascade |
B | 0060038 | biological_process | cardiac muscle cell proliferation |
B | 0060043 | biological_process | regulation of cardiac muscle cell proliferation |
B | 0060044 | biological_process | negative regulation of cardiac muscle cell proliferation |
B | 0060348 | biological_process | bone development |
B | 0071347 | biological_process | cellular response to interleukin-1 |
B | 0071493 | biological_process | cellular response to UV-B |
B | 0090398 | biological_process | cellular senescence |
B | 0098586 | biological_process | cellular response to virus |
B | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NA A 601 |
Chain | Residue |
A | HIS64 |
A | GLU81 |
A | ASP316 |
site_id | AC2 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE B45 A 365 |
Chain | Residue |
A | THR106 |
A | THR107 |
A | LEU108 |
A | MET109 |
A | GLY110 |
A | ALA111 |
A | SER154 |
A | ASN155 |
A | ALA157 |
A | LEU167 |
A | HOH626 |
A | VAL30 |
A | TYR35 |
A | VAL38 |
A | ALA51 |
A | LYS53 |
A | LEU104 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NA B 602 |
Chain | Residue |
B | HIS64 |
B | GLU81 |
B | ASP316 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 603 |
Chain | Residue |
A | HIS199 |
B | GLU245 |
B | ASP292 |
B | ASP294 |
site_id | AC5 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE B45 B 365 |
Chain | Residue |
B | VAL30 |
B | TYR35 |
B | VAL38 |
B | ALA51 |
B | VAL52 |
B | LYS53 |
B | LEU75 |
B | LEU104 |
B | THR106 |
B | THR107 |
B | LEU108 |
B | MET109 |
B | GLY110 |
B | ALA111 |
B | SER154 |
B | ALA157 |
B | LEU167 |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 25 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCsAydarlrqkv.........AVKK |
Chain | Residue | Details |
A | VAL30-LYS54 |
site_id | PS01351 |
Number of Residues | 104 |
Details | MAPK MAP kinase signature. FqsliharrtyRElrllkhlkhenviglldvftpatsiedfsevylvttlmgadlnnivksqalsdehvqflvyqllrglkyihsagiih.........RDlKpsnvavnedS |
Chain | Residue | Details |
A | PHE59-SER162 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
A | ASP150 | |
B | ASP150 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
A | VAL30 | |
A | LYS53 | |
B | VAL30 | |
B | LYS53 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: |
Chain | Residue | Details |
A | GLU71 | |
B | GLU71 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine; by MAP2K3, MAP2K4 and MAP2K6 => ECO:0000305|PubMed:15356147 |
Chain | Residue | Details |
A | THR180 | |
B | THR180 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Phosphotyrosine; by MAP2K3, MAP2K4 and MAP2K6 => ECO:0000305|PubMed:15356147 |
Chain | Residue | Details |
A | TYR182 | |
B | TYR182 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Phosphotyrosine; by ZAP70 => ECO:0000250 |
Chain | Residue | Details |
A | TYR323 | |
B | TYR323 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | SER154 | |
A | ASP150 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
B | SER154 | |
B | ASP150 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | LYS152 | |
A | ASP150 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
B | LYS152 | |
B | ASP150 |
site_id | CSA5 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | LYS152 | |
A | THR185 | |
A | ASP150 |
site_id | CSA6 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
B | LYS152 | |
B | THR185 | |
B | ASP150 |
site_id | CSA7 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | ASN155 | |
A | LYS152 | |
A | ASP150 |
site_id | CSA8 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
B | ASN155 | |
B | LYS152 | |
B | ASP150 |