3FYP

Crystal structure of the quadruple mutant (N23C/C246S/D247E/P249A) of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis

Summary for 3FYP

Entry DOI	10.2210/pdb3fyp/pdb
Related	2qkf
Descriptor	3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase, CHLORIDE ION, GLYCEROL, ... (7 entities in total)
Functional Keywords	manno-octulosonate, synthase, lipopolysaccharide, kdop, kdo8 kdops, kdo8ps, tim barrel, biosynthesis, transferase, lyase, lipopolysaccharide biosynthesis
Biological source	Neisseria meningitidis serogroup B
Cellular location	Cytoplasm (By similarity): Q9JZ55
Total number of polymer chains	4
Total formula weight	122445.22
Authors	Jameson, G.B.,Parker, E.J.,Cochrane, F.P.,Patchett, M.L. (deposition date: 2009-01-22, release date: 2009-03-31, Last modification date: 2023-09-06)
Primary citation	Cochrane, F.C.,Cookson, T.V.,Jameson, G.B.,Parker, E.J. Reversing evolution: re-establishing obligate metal ion dependence in a metal-independent KDO8P synthase J.Mol.Biol., 390:646-661, 2009 Cited by PubMed: 19447118 DOI: 10.1016/j.jmb.2009.05.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation