3FYP
Crystal structure of the quadruple mutant (N23C/C246S/D247E/P249A) of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008676 | molecular_function | 3-deoxy-8-phosphooctulonate synthase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019294 | biological_process | keto-3-deoxy-D-manno-octulosonic acid biosynthetic process |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008676 | molecular_function | 3-deoxy-8-phosphooctulonate synthase activity |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019294 | biological_process | keto-3-deoxy-D-manno-octulosonic acid biosynthetic process |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0008676 | molecular_function | 3-deoxy-8-phosphooctulonate synthase activity |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0019294 | biological_process | keto-3-deoxy-D-manno-octulosonic acid biosynthetic process |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0008676 | molecular_function | 3-deoxy-8-phosphooctulonate synthase activity |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0019294 | biological_process | keto-3-deoxy-D-manno-octulosonic acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 281 |
| Chain | Residue |
| A | HIS37 |
| A | HIS255 |
| A | LEU256 |
| A | LEU257 |
| A | GLU258 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 281 |
| Chain | Residue |
| B | LYS57 |
| B | GLU236 |
| B | SER237 |
| B | HOH451 |
| B | HOH766 |
| B | GLY21 |
| B | ILE22 |
| B | CYS23 |
| B | LYS52 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 2647 |
| Chain | Residue |
| B | LYS82 |
| B | ALA103 |
| B | GLU104 |
| B | VAL105 |
| B | ASP107 |
| B | ASN130 |
| B | HOH387 |
| B | HOH799 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA C 281 |
| Chain | Residue |
| B | HOH689 |
| C | ALA103 |
| C | CYS106 |
| C | ASN130 |
| C | HOH568 |
| C | HOH569 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PEP D 281 |
| Chain | Residue |
| D | LYS52 |
| D | SER54 |
| D | LYS57 |
| D | GLN110 |
| D | ALA113 |
| D | LYS135 |
| D | ARG165 |
| D | HIS199 |
| D | CL282 |
| D | HOH541 |
| D | HOH542 |
| D | HOH555 |
| D | HOH582 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL D 282 |
| Chain | Residue |
| D | LYS52 |
| D | GLN110 |
| D | LYS135 |
| D | HIS199 |
| D | PHE234 |
| D | PEP281 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA D 283 |
| Chain | Residue |
| B | SER168 |
| D | SER168 |
| D | GLY170 |
| D | HOH454 |
| D | HOH478 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN D 284 |
| Chain | Residue |
| D | CYS23 |
| D | HIS199 |
| D | GLU236 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| A | HIS199 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| B | HIS199 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| C | HIS199 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1q3n |
| Chain | Residue | Details |
| D | HIS199 |
