3FSF

P38 kinase crystal structure in complex with 3-(2,6-Dichloro-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-1-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one

3FSF の概要

• エントリーDOI: 10.2210/pdb3fsf/pdb
• 関連するPDBエントリー: 3FLN 3FLS 3FLW 3FLY 3FLZ 3FMH 3FMJ 3FMK 3FML 3FMM 3FMN
• 分子名称: Mitogen-activated protein kinase 14, 3-(2,6-dichlorophenyl)-7-({4-[(diethylamino)methoxy]phenyl}amino)-1-methyl-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (3 entities in total)
• 機能のキーワード: p38; map kinase; serine/threonine kinase, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase, signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm (By similarity): Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43250.12

構造登録者

Kuglstatter, A.,Bertrand, J.,Lovejoy, B. (登録日: 2009-01-09, 公開日: 2009-12-22, 最終更新日: 2023-09-06)

• 主引用文献: Soth, M.,Kuglstatter, A.,Goldstein, D.; The Discovery of Pamapimod and R1487 as Orally Bioavailable and Highly Selective Inhibitors of p38 Map Kinase; To be Published,

実験手法

X-RAY DIFFRACTION (2.1 Å)