Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3FMH

P38 kinase crystal structure in complex with 6-(2,4-Difluoro-phenoxy)-8-methyl-2-((R)-1-methyl-2-tetrazol-2-yl-ethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one

Summary for 3FMH
Entry DOI10.2210/pdb3fmh/pdb
Related3FLN 3FLQ 3FLS 3FLW 3FLY 3FLZ 3FMJ 3FMK
DescriptorMitogen-activated protein kinase 14, 6-(2,4-difluorophenoxy)-8-methyl-2-{[(1R)-1-methyl-2-(2H-tetrazol-2-yl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one (3 entities in total)
Functional Keywordsp38; map kinase; serine/threonine kinase, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, signaling protein
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight43163.08
Authors
Kuglstatter, A.,Ghate, M. (deposition date: 2008-12-22, release date: 2009-12-22, Last modification date: 2023-09-06)
Primary citationSoth, M.,Kuglstatter, A.,Goldstein, D.
The Discovery of Pamapimod and R1487 as Orally Bioavailable and Highly Selective Inhibitors of p38 Map Kinase
To be Published,
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon