3FMJ

P38 kinase crystal structure in complex with 4-(5-Methyl-3-phenyl-isoxazol-4-yl)-pyrimidin-2-ylamine

Summary for 3FMJ

• Entry DOI: 10.2210/pdb3fmj/pdb
• Related: 3FLN 3FLQ 3FLS 3FLW 3FLY 3FLZ 3FMH 3FMK
• Descriptor: Mitogen-activated protein kinase 14, 4-(5-methyl-3-phenylisoxazol-4-yl)pyrimidin-2-amine (3 entities in total)
• Functional Keywords: p38; map kinase; serine/threonine kinase, atp-binding, kinase, nucleotide-binding, nucleus, phosphoprotein, serine/threonine-protein kinase, transferase, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 43000.99

Authors

Kuglstatter, A.,Ghate, M. (deposition date: 2008-12-22, release date: 2009-12-22, Last modification date: 2023-09-06)

• Primary citation: Soth, M.,Kuglstatter, A.,Goldstein, D.; The Discovery of Pamapimod and R1487 as Orally Bioavailable and Highly Selective Inhibitors of p38 Map Kinase; To be Published,

Experimental method

X-RAY DIFFRACTION (2 Å)