3FQK

Hepatitis C virus polymerase NS5B (BK 1-570) with HCV-796 inhibitor

3FQK の概要

• エントリーDOI: 10.2210/pdb3fqk/pdb
• 関連するPDBエントリー: 2GIQ 2GIR 3FQL
• 分子名称: RNA-directed RNA polymerase, 5-cyclopropyl-2-(4-fluorophenyl)-6-[(2-hydroxyethyl)(methylsulfonyl)amino]-N-methyl-1-benzofuran-3-carboxamide (3 entities in total)
• 機能のキーワード: hcv, hepatitis, ns5b, transferase, rna-dependent rna polymerase, hcv-796
• 由来する生物種: Hepatitis C virus (HCV)
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26663
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 129246.29

構造登録者

Harris, S.F.,Wong, A. (登録日: 2009-01-07, 公開日: 2009-02-24, 最終更新日: 2023-09-06)

• 主引用文献: Hang, J.Q.,Yang, Y.,Harris, S.F.,Leveque, V.,Whittington, H.J.,Rajyaguru, S.,Ao-Ieong, G.,McCown, M.F.,Wong, A.,Giannetti, A.M.,Le Pogam, S.,Talamas, F.,Cammack, N.,Najera, I.,Klumpp, K.; Slow binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus.; J.Biol.Chem., 284:15517-15529, 2009; PubMed: 19246450; DOI: 10.1074/jbc.M808889200

実験手法

X-RAY DIFFRACTION (2.2 Å)