3FNV

Crystal Structure of Miner1: The Redox-active 2Fe-2S Protein Causative in Wolfram Syndrome 2

Summary for 3FNV

Entry DOI	10.2210/pdb3fnv/pdb
Related	2QH7
Descriptor	CDGSH iron sulfur domain-containing protein 2, FE2/S2 (INORGANIC) CLUSTER (3 entities in total)
Functional Keywords	diabetes, membrane bound, thiazolidinedione, oxidative stress, cdgsh, endoplasmic reticulum, iron, iron-sulfur, membrane, metal-binding, transmembrane, zinc-finger, metal binding protein
Biological source	Homo sapiens (Human)
Cellular location	Endoplasmic reticulum membrane; Single-pass membrane protein: Q8N5K1
Total number of polymer chains	2
Total formula weight	19331.73
Authors	Conlan, A.R.,Axelrod, H.L.,Cohen, A.E.,Abresch, E.C.,Yee, D.,Zuris, J.,Nechushtai, R.,Jennings, P.A.,Paddock, M.L. (deposition date: 2008-12-26, release date: 2009-08-18, Last modification date: 2024-02-21)
Primary citation	Conlan, A.R.,Axelrod, H.L.,Cohen, A.E.,Abresch, E.C.,Zuris, J.,Yee, D.,Nechushtai, R.,Jennings, P.A.,Paddock, M.L. Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2. J.Mol.Biol., 392:143-153, 2009 Cited by PubMed: 19580816 DOI: 10.1016/j.jmb.2009.06.079 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation