3FNV

Crystal Structure of Miner1: The Redox-active 2Fe-2S Protein Causative in Wolfram Syndrome 2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	CDGSH iron sulfur domain-containing protein 2	polymer	83	9490.0	2	UniProt (Q8N5K1) Pfam (PF09360)	Homo sapiens (Human)	Endoplasmic reticulum intermembrane small protein, MitoNEET-related 1 protein, Miner1
2	C, D (A, B)	FE2/S2 (INORGANIC) CLUSTER	non-polymer		175.8	2	Chemie (FES)
3	E, F (A, B)	water	water		18.0	40	Chemie (HOH)

Sequence modifications

A, B: 57 - 135 (UniProt: Q8N5K1)

PDB	External Database	Details
Gly 53	-	expression tag
Ser 54	-	expression tag
His 55	-	expression tag
Met 56	-	expression tag
Ser 92	Cys 92	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	18980.1
Non-Polymers*	Number of molecules	2
	Total formula weight	351.6
All*	Total formula weight	19331.7

*Water molecules are not included.