3FKZ

X-ray structure of the non covalent swapped form of the S16G/T17N/A19P/A20S/K31C/S32C mutant of bovine pancreatic ribonuclease

Summary for 3FKZ

Related1TQ9 3BCP 1BSR 1A2W 1H8X 3FL0 3FL1 3FL3
DescriptorRibonuclease pancreatic (2 entities in total)
Functional Keywords3d-domain swapping, bovine seminal ribonuclease, non-covalent dimer, antitumor activity, quaternary structure flexibility, protein mutations and evolution, endonuclease, glycation, glycoprotein, hydrolase, nuclease, secreted
Biological sourceBos taurus (Bovine)
Cellular locationSecreted P61823
Total number of polymer chains2
Total molecular weight27674.93
Authors
Merlino, A.,Russo Krauss, I.,Perillo, M.,Mattia, C.A.,Ercole, C.,Picone, D.,Vergara, A.,Sica, F. (deposition date: 2008-12-18, release date: 2009-03-24, Last modification date: 2011-07-13)
Primary citation
Merlino, A.,Russo Krauss, I.,Perillo, M.,Mattia, C.A.,Ercole, C.,Picone, D.,Vergara, A.,Sica, F.
Toward an antitumor form of bovine pancreatic ribonuclease: The crystal structure of three noncovalent dimeric mutants
Biopolymers, 91:1029-1037, 2009
PubMed: 19280639 (PDB entries with the same primary citation)
DOI: 10.1002/bip.21183
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.99 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.250190.4%7.9%4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
168889
PDB entries from 2020-09-16