3FK7
Crystal structure of TetR triple mutant (H64K, S135L, S138I) in complex with 4-ddma-atc
Summary for 3FK7
Entry DOI | 10.2210/pdb3fk7/pdb |
Related | 2O7O 2TCT 2VKE 2VKV 3FK6 |
Descriptor | Tetracycline repressor protein class B from transposon Tn10, Tetracycline repressor protein class D, MAGNESIUM ION, (4aS,12aS)-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydrotetracene-2-carboxamide, ... (4 entities in total) |
Functional Keywords | tetracycline repressor, bacterial transcription regulation, altered inducer specificity, 4-de-dimethylamino-anhydrotetracycline, antibiotic resistance, dna-binding, magnesium, metal-binding, repressor, transcription, transcription regulation, transposable element |
Biological source | Escherichia coli More |
Total number of polymer chains | 2 |
Total formula weight | 47712.91 |
Authors | Klieber, M.A.,Scholz, O.,Lochner, S.,Gmeiner, P.,Hillen, W.,Muller, Y.A. (deposition date: 2008-12-16, release date: 2009-11-03, Last modification date: 2023-11-01) |
Primary citation | Klieber, M.A.,Scholz, O.,Lochner, S.,Gmeiner, P.,Hillen, W.,Muller, Y.A. Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair. Febs J., 276:5610-5621, 2009 Cited by PubMed: 19712110DOI: 10.1111/j.1742-4658.2009.07254.x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
Download full validation report