3F8G

The X-ray structure of a dimeric variant of human pancreatic ribonuclease with high cytotoxic and antitumor activities

Summary for 3F8G

• Entry DOI: 10.2210/pdb3f8g/pdb
• Related: 1BSR 1E21 1R3M 2K11
• Descriptor: Ribonuclease pancreatic, SULFATE ION (3 entities in total)
• Functional Keywords: antitumor agent, ribonuclease, 3d domain swapping, unswapped dimer, dimers, endonuclease, glycoprotein, hydrolase, nuclease, secreted
• Biological source: Homo sapiens (human)
• Cellular location: Secreted: P07998
• Total number of polymer chains: 2
• Total formula weight: 28708.46

Authors

Merlino, A.,Avella, G.,Mazzarella, L.,Sica, F. (deposition date: 2008-11-12, release date: 2009-02-10, Last modification date: 2023-09-06)

• Primary citation: Merlino, A.,Avella, G.,Di Gaetano, S.,Arciello, A.,Piccoli, R.,Mazzarella, L.,Sica, F.; Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant.; Protein Sci., 18:50-57, 2009; PubMed: 19177350; DOI: 10.1002/pro.6

Experimental method

X-RAY DIFFRACTION (2.6 Å)