3F8G
The X-ray structure of a dimeric variant of human pancreatic ribonuclease with high cytotoxic and antitumor activities
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ribonuclease pancreatic | polymer | 125 | 14114.1 | 2 | UniProt (P07998) Pfam (PF00074) | Homo sapiens (human) | RNase 1, RNase A, RNase UpI-1, RIB-1, HP-RNase |
| 2 | C, D, E, F, G (A, B) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 3 | H, I (A, B) | water | water | 18.0 | 162 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 125 (UniProt: P07998)
| PDB | External Database | Details |
|---|---|---|
| Leu 28 | Gln 56 | engineered mutation |
| Cys 31 | Arg 59 | engineered mutation |
| Cys 32 | Arg 60 | engineered mutation |
| Lys 34 | Asn 62 | engineered mutation |
| Gly 111 | Glu 139 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28228.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 480.3 | |
| All* | Total formula weight | 28708.5 |
