3F6U
Crystal structure of human Activated Protein C (APC) complexed with PPACK
Summary for 3F6U
Entry DOI | 10.2210/pdb3f6u/pdb |
Related PRD ID | PRD_000020 |
Descriptor | Vitamin K-dependent protein C heavy chain, Vitamin K-dependent protein C light chain, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... (6 entities in total) |
Functional Keywords | blood coagulation, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens More |
Total number of polymer chains | 2 |
Total formula weight | 38285.32 |
Authors | Schmidt, A.E.,Padmanabhan, K.,Underwood, M.C.,Bode, W.,Mather, T.,Bajaj, S.P. (deposition date: 2008-11-06, release date: 2008-11-25, Last modification date: 2024-03-13) |
Primary citation | Schmidt, A.E.,Padmanabhan, K.,Underwood, M.C.,Bode, W.,Mather, T.,Bajaj, S.P. Thermodynamic linkage between the S1 site, the Na+ site, and the Ca2+ site in the protease domain of human activated protein C (APC). J.Biol.Chem., 277:28987-28995, 2002 Cited by PubMed: 12029084DOI: 10.1074/jbc.M201892200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
Download full validation report