3F6U

Crystal structure of human Activated Protein C (APC) complexed with PPACK

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0004252	molecular_function	serine-type endopeptidase activity
H	0006508	biological_process	proteolysis
L	0005509	molecular_function	calcium ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 0G6 H 1

Chain	Residue
H	HIS57
H	SER214
H	TRP215
H	GLY216
H	GLY219
H	HOH342
H	THR99
H	ASN174
H	ASP189
H	ALA190
H	CYS191
H	GLY193
H	ASP194
H	SER195

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA H 245

Chain	Residue
H	ILE184
H	ASP186
H	LEU221
H	ASN224
H	HOH339

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA H 246

Chain	Residue
H	GLU70
H	ASP72
H	ARG75
H	GLU80

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
H	LEU53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPMV

Chain	Residue	Details
H	ASP189-VAL200

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site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CiDgigsFsCdC

Chain	Residue	Details
L	CYS69-CYS80

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site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CdCrsGweGRfC

Chain	Residue	Details
L	CYS78-CYS89

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site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CdCrsGWegrf....C

Chain	Residue	Details
L	CYS78-CYS89
L	CYS118-CYS133

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
H	HIS57
H	ASP102
H	SER195

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039

Chain	Residue	Details
H	SER146

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:2991887

Chain	Residue	Details
H	ASN93

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:2991887

Chain	Residue	Details
H	ASN150

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; atypical; partial => ECO:0000269|PubMed:1694179, ECO:0000269|PubMed:2991887

Chain	Residue	Details
H	ASN166

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	SER195
H	HIS57

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	SER195
H	GLY196

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	SER195
H	GLY193
H	HIS57

---

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	ASP102
H	SER195
H	HIS57
H	GLY196

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