3EWJ

Crystal structure of catalytic domain of TACE with carboxylate inhibitor

Summary for 3EWJ

Entry DOI	10.2210/pdb3ewj/pdb
Related	1bkc 2fv9 3e8r
Related PRD ID	PRD_000919
Descriptor	ADAM 17, ZINC ION, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ... (5 entities in total)
Functional Keywords	tace, adam17, hydrolase, cleavage on pair of basic residues, glycoprotein, membrane, metal-binding, metalloprotease, notch signaling pathway, phosphoprotein, protease, sh3-binding, transmembrane, zymogen
Biological source	Homo sapiens (Human)
Cellular location	Membrane; Single-pass type I membrane protein: P78536
Total number of polymer chains	2
Total formula weight	62347.39
Authors	Orth, P. (deposition date: 2008-10-15, release date: 2008-11-18, Last modification date: 2023-09-06)
Primary citation	Guo, Z.,Orth, P.,Wong, S.C.,Lavey, B.J.,Shih, N.Y.,Niu, X.,Lundell, D.J.,Madison, V.,Kozlowski, J.A. Discovery of novel spirocyclopropyl hydroxamate and carboxylate compounds as TACE inhibitors. Bioorg.Med.Chem.Lett., 19:54-57, 2009 Cited by PubMed: 19054672 DOI: 10.1016/j.bmcl.2008.11.034 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation