3E8R

Crystal structure of catalytic domain of TACE with hydroxamate inhibitor

Summary for 3E8R

Entry DOI	10.2210/pdb3e8r/pdb
Related	2ddf 2fv5 2fv9
Related PRD ID	PRD_000919
Descriptor	ADAM 17, ZINC ION, (1R,2S)-N~2~-hydroxy-1-{4-[(2-phenylquinolin-4-yl)methoxy]benzyl}cyclopropane-1,2-dicarboxamide, ... (6 entities in total)
Functional Keywords	tace adam17 zn-endopeptidase, cleavage on pair of basic residues, glycoprotein, hydrolase, membrane, metal-binding, metalloprotease, notch signaling pathway, phosphoprotein, protease, sh3-binding, transmembrane, zymogen
Biological source	Homo sapiens (Human)
Cellular location	Membrane; Single-pass type I membrane protein: P78536
Total number of polymer chains	2
Total formula weight	63010.03
Authors	Orth, P. (deposition date: 2008-08-20, release date: 2008-10-21, Last modification date: 2021-10-20)
Primary citation	Mazzola, R.D.,Zhu, Z.,Sinning, L.,McKittrick, B.,Lavey, B.,Spitler, J.,Kozlowski, J.,Neng-Yang, S.,Zhou, G.,Guo, Z.,Orth, P.,Madison, V.,Sun, J.,Lundell, D.,Niu, X. Discovery of novel hydroxamates as highly potent tumor necrosis factor-alpha converting enzyme inhibitors. Part II: optimization of the S3' pocket. Bioorg.Med.Chem.Lett., 18:5809-5814, 2008 Cited by PubMed: 18835710 DOI: 10.1016/j.bmcl.2008.09.045 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation