2FV5
Crystal structure of TACE in complex with IK682
Summary for 2FV5
Entry DOI | 10.2210/pdb2fv5/pdb |
Related | 1bkc 2ddf |
Descriptor | ADAM 17, ZINC ION, (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE, ... (4 entities in total) |
Functional Keywords | tace adam17 zn-endopeptidase, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P78536 |
Total number of polymer chains | 2 |
Total formula weight | 59759.49 |
Authors | |
Primary citation | Niu, X.,Umland, S.,Ingram, R.,Beyer, B.M.,Liu, Y.H.,Sun, J.,Lundell, D.,Orth, P. IK682, a tight binding inhibitor of TACE. Arch.Biochem.Biophys., 451:43-50, 2006 Cited by PubMed: 16762314DOI: 10.1016/j.abb.2006.03.034 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report