2FV5
Crystal structure of TACE in complex with IK682
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | ADAM 17 | polymer | 261 | 29380.8 | 2 | UniProt (P78536) Pfam (PF13688) | Homo sapiens (human) | A disintegrin and metalloproteinase domain 17, TNF-alpha-converting enzyme, TNF-alpha convertase, Snake venom-like protease, CD156b antigen |
| 2 | C, E (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, F (A, B) | (2R)-N-HYDROXY-2-[(3S)-3-METHYL-3-{4-[(2-METHYLQUINOLIN-4-YL)METHOXY]PHENYL}-2-OXOPYRROLIDIN-1-YL]PROPANAMIDE | non-polymer | 433.5 | 2 | Chemie (541) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 414 | Chemie (HOH) |
Sequence modifications
A, B: 216 - 475 (UniProt: P78536)
| PDB | External Database | Details |
|---|---|---|
| Ala 266 | Ser 266 | engineered mutation |
| Gly 353 | Val 353 | engineered mutation |
| Gln 452 | Asn 452 | engineered mutation |
| Ala 476 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58761.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 997.8 | |
| All* | Total formula weight | 59759.5 |
