2DDF

Crystal structure of TACE in complex with TAPI-2

Summary for 2DDF

• Entry DOI: 10.2210/pdb2ddf/pdb
• Related: 1BKC
• Related PRD ID: PRD_000919
• Descriptor: ADAM 17, ZINC ION, CALCIUM ION, ... (8 entities in total)
• Functional Keywords: tace adam17 zn-endopeptidase, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P78536
• Total number of polymer chains: 2
• Total formula weight: 59522.52

Authors

Orth, P. (deposition date: 2006-01-28, release date: 2006-03-14, Last modification date: 2023-08-23)

• Primary citation: Ingram, R.N.,Orth, P.,Strickland, C.L.,Le, H.V.,Madison, V.,Beyer, B.M.; Stabilization of the autoproteolysis of TNF-alpha converting enzyme (TACE) results in a novel crystal form suitable for structure-based drug design studies.; Protein Eng.Des.Sel., 19:155-161, 2006; PubMed: 16459338; DOI: 10.1093/protein/gzj014

Experimental method

X-RAY DIFFRACTION (1.7 Å)