2DDF
Crystal structure of TACE in complex with TAPI-2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 1 |
| Chain | Residue |
| A | INN3 |
| A | HIS405 |
| A | HIS409 |
| A | HIS415 |
| A | HOH661 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 4 |
| Chain | Residue |
| B | HOH642 |
| B | INN2 |
| B | HIS405 |
| B | HIS409 |
| B | HIS415 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 475 |
| Chain | Residue |
| A | ASP342 |
| A | PHE343 |
| A | ASN389 |
| A | HOH659 |
| A | HOH660 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE INN B 2 |
| Chain | Residue |
| B | ZN4 |
| B | MET345 |
| B | GLY346 |
| B | THR347 |
| B | LEU348 |
| B | GLY349 |
| B | ASN389 |
| B | HIS405 |
| B | GLU406 |
| B | HIS409 |
| B | HIS415 |
| B | PRO437 |
| B | ILE438 |
| B | ALA439 |
| B | HOH630 |
| B | HOH642 |
| B | HOH645 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE INN A 3 |
| Chain | Residue |
| A | ZN1 |
| A | GLU327 |
| A | SER330 |
| A | MET345 |
| A | GLY346 |
| A | THR347 |
| A | LEU348 |
| A | GLY349 |
| A | ASN389 |
| A | TYR390 |
| A | HIS405 |
| A | GLU406 |
| A | HIS409 |
| A | HIS415 |
| A | PRO437 |
| A | ILE438 |
| A | ALA439 |
| A | HOH642 |
| A | HOH661 |
| A | HOH662 |
| A | HOH663 |
| A | HOH665 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IMD B 475 |
| Chain | Residue |
| B | ARG357 |
| B | ALA358 |
| B | ASN359 |
| B | CIT500 |
| B | HOH589 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CIT B 500 |
| Chain | Residue |
| A | PRO356 |
| A | HIS415 |
| A | PRO437 |
| B | ARG357 |
| B | ASN359 |
| B | SER360 |
| B | HIS361 |
| B | IMD475 |
| B | HOH631 |
| B | HOH643 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IPA B 501 |
| Chain | Residue |
| A | GLU280 |
| B | LEU420 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IPA A 476 |
| Chain | Residue |
| A | LEU285 |
| A | LYS286 |
| A | SER287 |
| A | PRO288 |
| A | GLN289 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IPA B 502 |
| Chain | Residue |
| B | LYS286 |
| B | SER287 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IPA B 503 |
| Chain | Residue |
| B | ILE279 |
| B | GLU280 |
| B | HOH646 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VTTHELGHNF |
| Chain | Residue | Details |
| A | VAL402-PHE411 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"9520379","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9520379","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
