3EPG

Structure of Human DNA Polymerase Iota complexed with N2-ethylguanine

3EPG の概要

• エントリーDOI: 10.2210/pdb3epg/pdb
• 関連するPDBエントリー: 2ALZ 2FLP 3epi
• 分子名称: DNA polymerase iota, 5'-D(*DTP*DCP*DTP*(2EG)P*DGP*DGP*DGP*DTP*DCP*DCP*DTP*DAP*DGP*DGP*DAP*DCP*DCP*(DOC))-3', 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: dna pol iota, lesion bypass, n2-ethylguanine, dna damage, dna repair, dna replication, dna synthesis, dna-binding, dna-directed dna polymerase, magnesium, metal-binding, mutator protein, nucleotidyltransferase, nucleus, schiff base, transferase, transferase-dna complex, transferase/dna
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: Q9UNA4
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 58627.67

構造登録者

Pence, M.G. (登録日: 2008-09-29, 公開日: 2008-12-16, 最終更新日: 2023-09-06)

• 主引用文献: Pence, M.G.,Blans, P.,Zink, C.N.,Hollis, T.,Fishbein, J.C.,Perrino, F.W.; Lesion bypass of N2-ethylguanine by human DNA polymerase iota.; J.Biol.Chem., 284:1732-1740, 2009; PubMed: 18984581; DOI: 10.1074/jbc.M807296200

実験手法

X-RAY DIFFRACTION (2.5 Å)