3EPG

Structure of Human DNA Polymerase Iota complexed with N2-ethylguanine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003684	molecular_function	damaged DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE DCP A 875

Chain	Residue
A	ASP34
A	LYS77
A	ASP126
A	LYS214
B	DOC13
C	2EG840
C	DG841
A	LEU35
A	CYS37
A	PHE38
A	TYR39
A	VAL64
A	THR65
A	TYR68
A	ARG71

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 421

Chain	Residue
A	LYS237
A	ILE239
A	ILE242
B	DC12

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA A 422

Chain	Residue
A	GLU115

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site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA C 1

Chain	Residue
C	DC845

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00216

Chain	Residue	Details
A	THR152

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:27555320, ECO:0007744|PDB:5KT5

Chain	Residue	Details
A	GLN59
A	LYS60
A	VAL151

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:15254543, ECO:0007744|PDB:1T3N

Chain	Residue	Details
A	VAL64
A	GLY96

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