3EPG

Structure of Human DNA Polymerase Iota complexed with N2-ethylguanine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003684	molecular_function	damaged DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE DCP A 875

Chain	Residue
A	ASP34
A	LYS77
A	ASP126
A	LYS214
B	DOC13
C	2EG840
C	DG841
A	LEU35
A	CYS37
A	PHE38
A	TYR39
A	VAL64
A	THR65
A	TYR68
A	ARG71

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 421

Chain	Residue
A	LYS237
A	ILE239
A	ILE242
B	DC12

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA A 422

Chain	Residue
A	GLU115

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA C 1

Chain	Residue
C	DC845

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	213
Details	Domain: {"description":"UmuC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00216","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	65
Details	Region: {"description":"DNA-binding","evidences":[{"source":"PubMed","id":"15254543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27555320","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T3N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KT2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KT6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00216","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27555320","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5KT5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15254543","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T3N","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---