3EM3
Crystal structure of amprenavir (APV) in complex with a drug resistant HIV-1 protease variant (I50L/A71V).
Summary for 3EM3
Entry DOI | 10.2210/pdb3em3/pdb |
Related | 3EKP 3EKQ 3EKT 3EKV 3EKW 3EKX 3EKY 3EL0 3EL1 3EL4 3EL5 3EM4 3EM6 |
Descriptor | Protease, ACETATE ION, {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER, ... (4 entities in total) |
Functional Keywords | protease inhibitor, hyper susceptibility, drug resistance, hiv, amprenavir, aids, hydrolase, protease |
Biological source | HIV-1 M:B_ARV2/SF2 (HIV-1) |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369 |
Total number of polymer chains | 2 |
Total formula weight | 22429.49 |
Authors | Prabu-Jeyabalan, M.,King, N.,Royer, C.,Schiffer, C. (deposition date: 2008-09-23, release date: 2009-09-01, Last modification date: 2023-09-06) |
Primary citation | Prabu-Jeyabalan, M.,King, N.,Bandaranayake, R.,Nalivaika, E.,Schiffer, C. Kinetic and Structural Studies on Atazanavir-specific I50L Drug-Resistant HIV-1 Protease Mutant To be Published, |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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