3EM4

Crystal structure of atazanavir (ATV) in complex with I50L/A71V drug-resistant HIV-1 protease

Summary for 3EM4

• Entry DOI: 10.2210/pdb3em4/pdb
• Related: 3EM3 3EM6
• Descriptor: Protease, (3S,8S,9S,12S)-3,12-BIS(1,1-DIMETHYLETHYL)-8-HYDROXY-4,11-DIOXO-9-(PHENYLMETHYL)-6-[[4-(2-PYRIDINYL)PHENYL]METHYL]-2,5, 6,10,13-PENTAAZATETRADECANEDIOIC ACID DIMETHYL ESTER, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: drug resistance, hypersusceptibility, protease inhibitor, hiv, atazanavir, aids, hydrolase, protease
• Biological source: HIV-1 M:B_ARV2/SF2 (HIV-1)
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• Total number of polymer chains: 4
• Total formula weight: 45393.77

Authors

Prabu-Jeyabalan, M.,King, N.,Royer, C.,Schiffer, C. (deposition date: 2008-09-23, release date: 2009-09-01, Last modification date: 2024-03-13)

• Primary citation: Prabu-Jeyabalan, M.,King, N.,Bandaranayake, R.,Nalivaika, E.,Schiffer, C.; Kinetic and Structural studies on atazanavir-specific I50L drug-resistant HIV-1 protease mutant; To be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)