3EM3
Crystal structure of amprenavir (APV) in complex with a drug resistant HIV-1 protease variant (I50L/A71V).
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Protease | polymer | 99 | 10843.8 | 2 | UniProt (P03369) Pfam (PF00077) | HIV-1 M:B_ARV2/SF2 (HIV-1) | Retropepsin, PR |
| 2 | C, D, E, F (A) | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) PubChem (175) | |||
| 3 | G (B) | {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER | non-polymer | 505.6 | 1 | Chemie (478) PubChem (22868212) PubChem (44342222) PubChem (68164690) PubChem (441385) PubChem (124638074) PubChem (10885665) PubChem (11168069) PubChem (59964701) PubChem (68088939) PubChem (68336859) PubChem (92209736) PubChem (2177) PubChem (65016) PubChem (6540587) PubChem (9898472) PubChem (141823677) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 86 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03369)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 497 | engineered mutation |
| Leu 50 | Ile 540 | engineered mutation |
| Ile 64 | Val 554 | engineered mutation |
| Val 71 | Ala 561 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21687.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 741.8 | |
| All* | Total formula weight | 22429.5 |
