Glycogen Phosphorylase b/Chrysin complex

Summary for 3EBO

Related1c8k 1e1y 3EBP
DescriptorGlycogen phosphorylase, muscle form, chrysin (3 entities in total)
Functional Keywordsglycogen phosphorylase, catalytic site, rational inhibitor design, glycogenolysis, diabetes type 2, allosteric enzyme, carbohydrate metabolism, glycogen metabolism, glycosyltransferase, nucleotide-binding, phosphoprotein, pyridoxal phosphate, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceOryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
Total number of polymer chains1
Total molecular weight97773.56
Oikonomakos, N.G.,Zographos, S.E.,Leonidas, D.D.,Hayes, J.M.,Tiraidis, C.,Alexacou, K.-M. (deposition date: 2008-08-28, release date: 2009-09-01, Last modification date: 2018-05-16)
Primary citation
Tsitsanou, K.E.,Hayes, J.M.,Keramioti, M.,Mamais, M.,Oikonomakos, N.G.,Kato, A.,Leonidas, D.D.,Zographos, S.E.
Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: Comparison of chrysin and flavopiridol
Food Chem.Toxicol., 61:14-27, 2013
PubMed: 23279842 (PDB entries with the same primary citation)
DOI: 10.1016/j.fct.2012.12.030
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21810 4.3% 6.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-21