3E9S
A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication
Summary for 3E9S
Entry DOI | 10.2210/pdb3e9s/pdb |
Related | 2FE8 |
Descriptor | Non-structural protein 3, 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, ZINC ION, ... (5 entities in total) |
Functional Keywords | sars, virus, coronavirus, papain, papain-like, protease, plpro, nsp3, cytoplasm, hydrolase, membrane, metal-binding, ribosomal frameshifting, rna-binding, thiol protease, transmembrane, zinc, zinc-finger |
Biological source | SARS coronavirus (SARS-CoV) |
Cellular location | Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity): P0C6U8 |
Total number of polymer chains | 1 |
Total formula weight | 36167.13 |
Authors | Mesecar, A.D.,Ratia, K.,Pegan, S. (deposition date: 2008-08-23, release date: 2008-10-07, Last modification date: 2011-07-13) |
Primary citation | Mesecar, A.D.,Ratia, K.,Pegan, S. A new class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication To be published, |
Experimental method |
Structure validation
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