3E0V

Crystal structure of pyruvate kinase from Leishmania mexicana in complex with sulphate ions

Summary for 3E0V

• Entry DOI: 10.2210/pdb3e0v/pdb
• Related: 3E0W
• Descriptor: Pyruvate kinase, SULFATE ION, GLYCEROL, ... (4 entities in total)
• Functional Keywords: pyruvate, kinase, nad+ nadh, adp, phosphoenolpyruvate, pep, glycolysis, trypanosomatid, leishmania, mexicana, allosteric enzyme, magnesium, metal-binding, transferase
• Biological source: Leishmania mexicana
• Total number of polymer chains: 6
• Total formula weight: 357325.42

Authors

Tulloch, L.B.,Gillmore, L.A.,Walkinshaw, M.D. (deposition date: 2008-08-01, release date: 2008-08-19, Last modification date: 2023-08-30)

• Primary citation: Tulloch, L.B.,Morgan, H.P.,Hannaert, V.,Michels, P.A.,Fothergill-Gilmore, L.A.,Walkinshaw, M.D.; Sulphate removal induces a major conformational change in Leishmania mexicana pyruvate kinase in the crystalline state.; J.Mol.Biol., 383:615-626, 2008; PubMed: 18775437; DOI: 10.1016/j.jmb.2008.08.037

Experimental method

X-RAY DIFFRACTION (3.3 Å)