Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3E0V

Crystal structure of pyruvate kinase from Leishmania mexicana in complex with sulphate ions

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0004743	molecular_function	pyruvate kinase activity
A	0005524	molecular_function	ATP binding
A	0006096	biological_process	glycolytic process
A	0006950	biological_process	response to stress
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0030955	molecular_function	potassium ion binding
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0004743	molecular_function	pyruvate kinase activity
B	0005524	molecular_function	ATP binding
B	0006096	biological_process	glycolytic process
B	0006950	biological_process	response to stress
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0030955	molecular_function	potassium ion binding
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0003824	molecular_function	catalytic activity
C	0004743	molecular_function	pyruvate kinase activity
C	0005524	molecular_function	ATP binding
C	0006096	biological_process	glycolytic process
C	0006950	biological_process	response to stress
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0030955	molecular_function	potassium ion binding
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0004743	molecular_function	pyruvate kinase activity
D	0005524	molecular_function	ATP binding
D	0006096	biological_process	glycolytic process
D	0006950	biological_process	response to stress
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0030955	molecular_function	potassium ion binding
D	0046872	molecular_function	metal ion binding
E	0000166	molecular_function	nucleotide binding
E	0000287	molecular_function	magnesium ion binding
E	0003824	molecular_function	catalytic activity
E	0004743	molecular_function	pyruvate kinase activity
E	0005524	molecular_function	ATP binding
E	0006096	biological_process	glycolytic process
E	0006950	biological_process	response to stress
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0030955	molecular_function	potassium ion binding
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0000287	molecular_function	magnesium ion binding
F	0003824	molecular_function	catalytic activity
F	0004743	molecular_function	pyruvate kinase activity
F	0005524	molecular_function	ATP binding
F	0006096	biological_process	glycolytic process
F	0006950	biological_process	response to stress
F	0016301	molecular_function	kinase activity
F	0016740	molecular_function	transferase activity
F	0030955	molecular_function	potassium ion binding
F	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 501

Chain	Residue
A	ARG49
A	ASN51
A	LYS238

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 502

Chain	Residue
A	GLN297
A	GLU300
A	SER330
A	GLY331
A	GLU332

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 503

Chain	Residue
A	ARG174
A	HIS54

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 506

Chain	Residue
A	HIS54
A	ARG90
A	ARG175

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 507

Chain	Residue
A	SER400
A	ASN401
A	THR402
A	GLY403
A	ARG404
A	SER405
A	ALA481
A	ASP482

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 508

Chain	Residue
A	LYS453
A	ARG456

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 504

Chain	Residue
A	SER1
A	GLN2
B	GLN2
B	HOH1113

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 501

Chain	Residue
B	ARG49
B	ASN51
B	SER53
B	LYS238

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 502

Chain	Residue
B	GLN297
B	GLU300
B	GLY331
B	GLU332

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 503

Chain	Residue
B	SER53
B	HIS54
B	ARG174
B	HOH1100

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 505

Chain	Residue
B	ASN178
B	LEU179
B	PRO180
B	VAL184
B	GLU268

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 506

Chain	Residue
B	HIS54
B	ARG90
B	ARG175
B	LYS335

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 507

Chain	Residue
B	SER400
B	ASN401
B	THR402
B	GLY403
B	ARG404
B	SER405
B	ALA481
B	ASP482

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 B 508

Chain	Residue
B	ARG456

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 501

Chain	Residue
C	ARG49
C	ASN51
C	LYS238

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 502

Chain	Residue
C	GLN297
C	GLU300
C	GLY331
C	GLU332

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 503

Chain	Residue
C	SER53
C	HIS54
C	GLY55
C	ARG174

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 505

Chain	Residue
C	ASN178
C	LEU179
C	VAL184
C	ARG214
C	GLN243
C	GLU268

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 506

Chain	Residue
C	HIS54
C	ARG90
C	ARG175

site_id	CC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 507

Chain	Residue
C	SER400
C	ASN401
C	THR402
C	GLY403
C	ARG404
C	SER405
C	ALA481
C	ASP482

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 508

Chain	Residue
C	ASN401
C	ARG456

site_id	CC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 504

Chain	Residue
C	GLN2
D	GLN2
D	HOH2149

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 501

Chain	Residue
D	ARG49
D	ASN51
D	SER53
D	LYS238

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 502

Chain	Residue
D	GLN297
D	GLU300
D	SER330
D	GLY331
D	GLU332

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 503

Chain	Residue
D	HIS54
D	GLY55
D	HOH2132

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 505

Chain	Residue
D	ASN178
D	ASN241
D	GLN243
D	GLU268

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 506

Chain	Residue
D	HIS54
D	ARG90
D	ARG175
D	LYS335

site_id	DC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D 507

Chain	Residue
D	SER400
D	ASN401
D	THR402
D	GLY403
D	ARG404
D	SER405
D	ALA481
D	ASP482

site_id	DC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 501

Chain	Residue
E	ARG49
E	ASN51
E	LYS238

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 502

Chain	Residue
E	GLN297
E	SER330
E	GLY331
E	GLU332

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 503

Chain	Residue
E	SER53
E	HIS54
E	ARG174

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 504

Chain	Residue
E	GLN2
E	HOH3040
E	HOH4135
F	GLN2

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 506

Chain	Residue
E	HIS54
E	ARG90
E	ARG175

site_id	DC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 E 507

Chain	Residue
E	SER400
E	ASN401
E	THR402
E	GLY403
E	ARG404
E	SER405
E	ALA481
E	ASP482

site_id	DC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 501

Chain	Residue
F	ARG49
F	ASN51
F	ASP83
F	LYS238
F	SO4506

site_id	DC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 502

Chain	Residue
F	GLN297
F	GLU300
F	GLY331
F	GLU332

site_id	EC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 F 503

Chain	Residue
F	SER53
F	HIS54
F	ARG174

site_id	EC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 506

Chain	Residue
F	HIS54
F	ARG90
F	ARG175
F	SO4501

site_id	EC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 F 507

Chain	Residue
F	SER400
F	ASN401
F	THR402
F	GLY403
F	ARG404
F	SER405
F	ALA481
F	ASP482

site_id	EC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 F 508

Chain	Residue
F	LYS453
F	ARG456

site_id	EC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 509

Chain	Residue
A	SER56
D	LYS123
D	GLU156

site_id	EC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 510

Chain	Residue
A	ASN178
A	LEU179
A	CYS182
A	VAL184
A	ARG214
A	GLN243
A	GLU268

site_id	EC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL E 508

Chain	Residue
A	PHE115
A	LYS123
E	GLY55
E	SER56
E	HOH3046
E	HOH4110

Functional Information from PROSITE/UniProt

site_id	PS00110
Number of Residues	13
Details	PYRUVATE_KINASE Pyruvate kinase active site signature. ImIICKIENhQGV

Chain	Residue	Details
A	ILE233-VAL245

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	54
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P14618","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Site: {"description":"Transition state stabilizer"}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	6
Details	Annotated By Reference To The Literature 1pkn

Chain	Residue	Details
A	ARG90
A	LYS238
A	ARG49
A	THR296
A	GLU332
A	SER330

site_id	CSA2
Number of Residues	6
Details	Annotated By Reference To The Literature 1pkn

Chain	Residue	Details
B	ARG90
B	LYS238
B	ARG49
B	THR296
B	GLU332
B	SER330

site_id	CSA3
Number of Residues	6
Details	Annotated By Reference To The Literature 1pkn

Chain	Residue	Details
C	ARG90
C	LYS238
C	ARG49
C	THR296
C	GLU332
C	SER330

site_id	CSA4
Number of Residues	6
Details	Annotated By Reference To The Literature 1pkn

Chain	Residue	Details
D	ARG90
D	LYS238
D	ARG49
D	THR296
D	GLU332
D	SER330

site_id	CSA5
Number of Residues	6
Details	Annotated By Reference To The Literature 1pkn

Chain	Residue	Details
E	ARG90
E	LYS238
E	ARG49
E	THR296
E	GLU332
E	SER330

site_id	CSA6
Number of Residues	6
Details	Annotated By Reference To The Literature 1pkn

Chain	Residue	Details
F	ARG90
F	LYS238
F	ARG49
F	THR296
F	GLU332
F	SER330

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)