Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0004743 | molecular_function | pyruvate kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0006096 | biological_process | glycolytic process |
A | 0016301 | molecular_function | kinase activity |
A | 0030955 | molecular_function | potassium ion binding |
A | 0046872 | molecular_function | metal ion binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004743 | molecular_function | pyruvate kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0006096 | biological_process | glycolytic process |
B | 0016301 | molecular_function | kinase activity |
B | 0030955 | molecular_function | potassium ion binding |
B | 0046872 | molecular_function | metal ion binding |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0003824 | molecular_function | catalytic activity |
C | 0004743 | molecular_function | pyruvate kinase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0006096 | biological_process | glycolytic process |
C | 0016301 | molecular_function | kinase activity |
C | 0030955 | molecular_function | potassium ion binding |
C | 0046872 | molecular_function | metal ion binding |
D | 0000287 | molecular_function | magnesium ion binding |
D | 0003824 | molecular_function | catalytic activity |
D | 0004743 | molecular_function | pyruvate kinase activity |
D | 0005524 | molecular_function | ATP binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0006096 | biological_process | glycolytic process |
D | 0016301 | molecular_function | kinase activity |
D | 0030955 | molecular_function | potassium ion binding |
D | 0046872 | molecular_function | metal ion binding |
E | 0000287 | molecular_function | magnesium ion binding |
E | 0003824 | molecular_function | catalytic activity |
E | 0004743 | molecular_function | pyruvate kinase activity |
E | 0005524 | molecular_function | ATP binding |
E | 0005737 | cellular_component | cytoplasm |
E | 0006096 | biological_process | glycolytic process |
E | 0016301 | molecular_function | kinase activity |
E | 0030955 | molecular_function | potassium ion binding |
E | 0046872 | molecular_function | metal ion binding |
F | 0000287 | molecular_function | magnesium ion binding |
F | 0003824 | molecular_function | catalytic activity |
F | 0004743 | molecular_function | pyruvate kinase activity |
F | 0005524 | molecular_function | ATP binding |
F | 0005737 | cellular_component | cytoplasm |
F | 0006096 | biological_process | glycolytic process |
F | 0016301 | molecular_function | kinase activity |
F | 0030955 | molecular_function | potassium ion binding |
F | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 501 |
Chain | Residue |
A | ARG49 |
A | ASN51 |
A | LYS238 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 A 502 |
Chain | Residue |
A | GLN297 |
A | GLU300 |
A | SER330 |
A | GLY331 |
A | GLU332 |
site_id | AC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 A 503 |
Chain | Residue |
A | ARG174 |
A | HIS54 |
site_id | AC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 506 |
Chain | Residue |
A | HIS54 |
A | ARG90 |
A | ARG175 |
site_id | AC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 A 507 |
Chain | Residue |
A | SER400 |
A | ASN401 |
A | THR402 |
A | GLY403 |
A | ARG404 |
A | SER405 |
A | ALA481 |
A | ASP482 |
site_id | AC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 A 508 |
Chain | Residue |
A | LYS453 |
A | ARG456 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 504 |
Chain | Residue |
A | SER1 |
A | GLN2 |
B | GLN2 |
B | HOH1113 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 501 |
Chain | Residue |
B | ARG49 |
B | ASN51 |
B | SER53 |
B | LYS238 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 502 |
Chain | Residue |
B | GLN297 |
B | GLU300 |
B | GLY331 |
B | GLU332 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 503 |
Chain | Residue |
B | SER53 |
B | HIS54 |
B | ARG174 |
B | HOH1100 |
site_id | BC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 505 |
Chain | Residue |
B | ASN178 |
B | LEU179 |
B | PRO180 |
B | VAL184 |
B | GLU268 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 B 506 |
Chain | Residue |
B | HIS54 |
B | ARG90 |
B | ARG175 |
B | LYS335 |
site_id | BC4 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 B 507 |
Chain | Residue |
B | SER400 |
B | ASN401 |
B | THR402 |
B | GLY403 |
B | ARG404 |
B | SER405 |
B | ALA481 |
B | ASP482 |
site_id | BC5 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE SO4 B 508 |
site_id | BC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 C 501 |
Chain | Residue |
C | ARG49 |
C | ASN51 |
C | LYS238 |
site_id | BC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 C 502 |
Chain | Residue |
C | GLN297 |
C | GLU300 |
C | GLY331 |
C | GLU332 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 C 503 |
Chain | Residue |
C | SER53 |
C | HIS54 |
C | GLY55 |
C | ARG174 |
site_id | BC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 C 505 |
Chain | Residue |
C | ASN178 |
C | LEU179 |
C | VAL184 |
C | ARG214 |
C | GLN243 |
C | GLU268 |
site_id | CC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 C 506 |
Chain | Residue |
C | HIS54 |
C | ARG90 |
C | ARG175 |
site_id | CC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 C 507 |
Chain | Residue |
C | SER400 |
C | ASN401 |
C | THR402 |
C | GLY403 |
C | ARG404 |
C | SER405 |
C | ALA481 |
C | ASP482 |
site_id | CC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 C 508 |
Chain | Residue |
C | ASN401 |
C | ARG456 |
site_id | CC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 D 504 |
Chain | Residue |
C | GLN2 |
D | GLN2 |
D | HOH2149 |
site_id | CC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 D 501 |
Chain | Residue |
D | ARG49 |
D | ASN51 |
D | SER53 |
D | LYS238 |
site_id | CC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 D 502 |
Chain | Residue |
D | GLN297 |
D | GLU300 |
D | SER330 |
D | GLY331 |
D | GLU332 |
site_id | CC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 D 503 |
Chain | Residue |
D | HIS54 |
D | GLY55 |
D | HOH2132 |
site_id | CC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 D 505 |
Chain | Residue |
D | ASN178 |
D | ASN241 |
D | GLN243 |
D | GLU268 |
site_id | CC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 D 506 |
Chain | Residue |
D | HIS54 |
D | ARG90 |
D | ARG175 |
D | LYS335 |
site_id | DC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 D 507 |
Chain | Residue |
D | SER400 |
D | ASN401 |
D | THR402 |
D | GLY403 |
D | ARG404 |
D | SER405 |
D | ALA481 |
D | ASP482 |
site_id | DC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 E 501 |
Chain | Residue |
E | ARG49 |
E | ASN51 |
E | LYS238 |
site_id | DC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 E 502 |
Chain | Residue |
E | GLN297 |
E | SER330 |
E | GLY331 |
E | GLU332 |
site_id | DC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 E 503 |
Chain | Residue |
E | SER53 |
E | HIS54 |
E | ARG174 |
site_id | DC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 E 504 |
Chain | Residue |
E | GLN2 |
E | HOH3040 |
E | HOH4135 |
F | GLN2 |
site_id | DC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 E 506 |
Chain | Residue |
E | HIS54 |
E | ARG90 |
E | ARG175 |
site_id | DC7 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 E 507 |
Chain | Residue |
E | SER400 |
E | ASN401 |
E | THR402 |
E | GLY403 |
E | ARG404 |
E | SER405 |
E | ALA481 |
E | ASP482 |
site_id | DC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 F 501 |
Chain | Residue |
F | ARG49 |
F | ASN51 |
F | ASP83 |
F | LYS238 |
F | SO4506 |
site_id | DC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 F 502 |
Chain | Residue |
F | GLN297 |
F | GLU300 |
F | GLY331 |
F | GLU332 |
site_id | EC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 F 503 |
Chain | Residue |
F | SER53 |
F | HIS54 |
F | ARG174 |
site_id | EC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 F 506 |
Chain | Residue |
F | HIS54 |
F | ARG90 |
F | ARG175 |
F | SO4501 |
site_id | EC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 F 507 |
Chain | Residue |
F | SER400 |
F | ASN401 |
F | THR402 |
F | GLY403 |
F | ARG404 |
F | SER405 |
F | ALA481 |
F | ASP482 |
site_id | EC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 F 508 |
Chain | Residue |
F | LYS453 |
F | ARG456 |
site_id | EC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 509 |
Chain | Residue |
A | SER56 |
D | LYS123 |
D | GLU156 |
site_id | EC6 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 510 |
Chain | Residue |
A | ASN178 |
A | LEU179 |
A | CYS182 |
A | VAL184 |
A | ARG214 |
A | GLN243 |
A | GLU268 |
site_id | EC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL E 508 |
Chain | Residue |
A | PHE115 |
A | LYS123 |
E | GLY55 |
E | SER56 |
E | HOH3046 |
E | HOH4110 |
Functional Information from PROSITE/UniProt
site_id | PS00110 |
Number of Residues | 13 |
Details | PYRUVATE_KINASE Pyruvate kinase active site signature. ImIICKIENhQGV |
Chain | Residue | Details |
A | ILE233-VAL245 | |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 54 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | ARG49 | |
B | ARG49 | |
B | ASN51 | |
B | SER53 | |
B | ASP83 | |
B | THR84 | |
B | GLU240 | |
B | GLY263 | |
B | ASP264 | |
B | THR296 | |
C | ARG49 | |
A | ASN51 | |
C | ASN51 | |
C | SER53 | |
C | ASP83 | |
C | THR84 | |
C | GLU240 | |
C | GLY263 | |
C | ASP264 | |
C | THR296 | |
D | ARG49 | |
D | ASN51 | |
A | SER53 | |
D | SER53 | |
D | ASP83 | |
D | THR84 | |
D | GLU240 | |
D | GLY263 | |
D | ASP264 | |
D | THR296 | |
E | ARG49 | |
E | ASN51 | |
E | SER53 | |
A | ASP83 | |
E | ASP83 | |
E | THR84 | |
E | GLU240 | |
E | GLY263 | |
E | ASP264 | |
E | THR296 | |
F | ARG49 | |
F | ASN51 | |
F | SER53 | |
F | ASP83 | |
A | THR84 | |
F | THR84 | |
F | GLU240 | |
F | GLY263 | |
F | ASP264 | |
F | THR296 | |
A | GLU240 | |
A | GLY263 | |
A | ASP264 | |
A | THR296 | |
Chain | Residue | Details |
A | ARG90 | |
B | ARG90 | |
C | ARG90 | |
D | ARG90 | |
E | ARG90 | |
F | ARG90 | |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | SITE: Transition state stabilizer |
Chain | Residue | Details |
A | LYS238 | |
B | LYS238 | |
C | LYS238 | |
D | LYS238 | |
E | LYS238 | |
F | LYS238 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 6 |
Details | Annotated By Reference To The Literature 1pkn |
Chain | Residue | Details |
A | ARG90 | |
A | LYS238 | |
A | ARG49 | |
A | THR296 | |
A | GLU332 | |
A | SER330 | |
site_id | CSA2 |
Number of Residues | 6 |
Details | Annotated By Reference To The Literature 1pkn |
Chain | Residue | Details |
B | ARG90 | |
B | LYS238 | |
B | ARG49 | |
B | THR296 | |
B | GLU332 | |
B | SER330 | |
site_id | CSA3 |
Number of Residues | 6 |
Details | Annotated By Reference To The Literature 1pkn |
Chain | Residue | Details |
C | ARG90 | |
C | LYS238 | |
C | ARG49 | |
C | THR296 | |
C | GLU332 | |
C | SER330 | |
site_id | CSA4 |
Number of Residues | 6 |
Details | Annotated By Reference To The Literature 1pkn |
Chain | Residue | Details |
D | ARG90 | |
D | LYS238 | |
D | ARG49 | |
D | THR296 | |
D | GLU332 | |
D | SER330 | |
site_id | CSA5 |
Number of Residues | 6 |
Details | Annotated By Reference To The Literature 1pkn |
Chain | Residue | Details |
E | ARG90 | |
E | LYS238 | |
E | ARG49 | |
E | THR296 | |
E | GLU332 | |
E | SER330 | |
site_id | CSA6 |
Number of Residues | 6 |
Details | Annotated By Reference To The Literature 1pkn |
Chain | Residue | Details |
F | ARG90 | |
F | LYS238 | |
F | ARG49 | |
F | THR296 | |
F | GLU332 | |
F | SER330 | |