3DZQ
Human EphA3 kinase domain in complex with inhibitor AWL-II-38.3
Summary for 3DZQ
Entry DOI | 10.2210/pdb3dzq/pdb |
Related | 2GSF 2QO2 2QO7 2QO9 2QOC 2QOD 2QOF 2QOI 2QOK 2QOL 2QON 2QOO 2QOQ |
Descriptor | EPH receptor A3, N-[2-methyl-5-({[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]carbonyl}amino)phenyl]isoxazole-5-carboxamide (3 entities in total) |
Functional Keywords | receptor tyrosine kinase, structural genomics consortium, sgc, atp-binding, membrane, nucleotide binding, phosphorylation, transferase, transmembrane, tyrosine-protein kinase, inhibitor-complex, nucleotide-binding, phosphoprotein |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 40927.60 |
Authors | Walker, J.R.,Syeda, F.,Gray, N.,Mansoor, W.,Mackenzie, F.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (deposition date: 2008-07-30, release date: 2008-08-26, Last modification date: 2023-08-30) |
Primary citation | Walker, J.R.,Syeda, F.,Gray, N.,Mansoor, W.,Mackenzie, F.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S. Kinase Domain of Human Ephrin Type-A Receptor 3 (Epha3) in Complex with ALW-II-38-3. To be Published, |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
Download full validation report