3DV1
Crystal structure of human beta-secretase in complex with NVP-ARV999
Summary for 3DV1
Entry DOI | 10.2210/pdb3dv1/pdb |
Related | 3DUY 3DV5 |
Descriptor | Beta-secretase 1, (2R,4S)-N-butyl-4-[(2S,5S,7R)-2,7-dimethyl-3,15-dioxo-1,4-diazacyclopentadecan-5-yl]-4-hydroxy-2-methylbutanamide (3 entities in total) |
Functional Keywords | beta-secretase, bace1, memapsin2, aspartic protease, enzyme inhibitor complex, alzheimer's disease, alternative splicing, aspartyl protease, glycoprotein, hydrolase, membrane, transmembrane, zymogen |
Biological source | Homo sapiens |
Cellular location | Membrane; Single-pass type I membrane protein: P56817 |
Total number of polymer chains | 3 |
Total formula weight | 135650.90 |
Authors | Rondeau, J.-M. (deposition date: 2008-07-18, release date: 2009-02-24, Last modification date: 2023-08-30) |
Primary citation | Machauer, R.,Laumen, K.,Veenstra, S.,Rondeau, J.M.,Tintelnot-Blomley, M.,Betschart, C.,Jaton, A.L.,Desrayaud, S.,Staufenbiel, M.,Rabe, S.,Paganetti, P.,Neumann, U. Macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors with activity in vivo. Bioorg.Med.Chem.Lett., 19:1366-1370, 2009 Cited by PubMed: 19195887DOI: 10.1016/j.bmcl.2009.01.055 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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